First of all, I think the new design is amazing. It elegantly combines the fantasy and sci-fi settings that tend to be prominent in RPG's, and also uses the pencil drawings at the bottom corners of the header to help show that this site is for pencil and paper RPGs and NOT video-game RPGs like World of Warcraft.
So far, the only thing I've noticed that I dislike is the font that shows user reputation in posts. The 3's and 5's just seem to blend in with the adjacent numbers a little, which makes them harder to read. Granted, this is an extreme nitpick in the amazing design, and I'll probably get used to it over time, but I wanted to see if anybody else agreed with me about the decrease in legibility. :D