Specifics are not important for so general a question, but I was responding to a comment from another user under one of my answers and realized that I didn't know. This user seemed upset with my answer and so while I wanted to provide some context for my reasoning I certainly did not want to bother them with additional comment notifications.
If you ping a user in a comment, post it, and then later edit that comment, does it ping the user a second time when the edited comment is submitted?